It is a melodic ballad and was released in October 1995 by Warner Bros. as the second single from the album.

It is the only song from One Hot Minute to be included on their Greatest Hits compilation, though the music video for "Aeroplane" appears on the DVD.

"[1] The surreal original music video for "My Friends" depicts the band in many incarnations on a small boat, stranded in a large stretch of treacherous water.

On October 2, 2021, Chad Smith and Dave Navarro performed "My Friends" together for the first time in 25 years at the Ohana Festival.

They were joined by Taylor Hawkins on vocals, Pat Smear on guitar and Chris Chaney on bass.