The album features production by Mike Dean, Mr. Lee, N.O.

Upon its release, My Homies peaked at number 4 on the US Billboard 200, becoming a certified platinum by the Recording Industry Association of America (RIAA) as of April 6, 1998.

The album features guest performances from 2Pac, Master P, Ice Cube, Devin the Dude, B-Legit, UGK, Too Short, Do or Die, and Willie D. Scarface appeared solo onto two out of thirty songs, while performing with others on thirteen (track 11 only having him talk over the beat) and does not contribute vocals on fifteen (Scarface is not on tracks 2, 3, 9, 10, 13, 14, 15, 16, 17, 19, 21, 25, 27, 28, 30).

Along with singles, music videos were produced for the songs: "Homies & Thuggs", featuring 2Pac and Master P and "Sex Faces", featuring Too Short, Tela and Devin the Dude.

The song, "Sleepin' In My Nikes", was originally released on the Seagram album, Souls on Ice.