His friend Dr. Carl Miller (Henry Beckman), a scientist with the U.S. Air Force being transferred to Pakistan, shows Bob his latest invention: a lifelike android in the form of a sexy, Amazonian female, AF 709.

[7] The New York Times, reviewing the show in September, said it: ...very probably has the makings of a popular novelty hit... with Miss Newmar giving a light and amusing performance as the automated dish, the premise could work out... Bob Cummings, an old hand at chaperoning pretty girls, again is cast in his familiar assignment.

[9] The show was initially scheduled opposite NBC's Bonanza on Sunday nights, but was shifted to Wednesdays in December in an attempt to improve ratings.

[13] However, this is denied by Newmar and show producer Howard Leeds[14] in The Living Doll Story, a featurette included in the 2012 DVD release.

On March 20, 2012, MPI Home Video released My Living Doll—The Official Collection, Volume 1 on DVD in Region 1.

[22] The episodes featured on the DVD collection were created from 16mm prints of the show held by collectors, as the one known set of original 35mm negatives were destroyed in the 1994 Northridge earthquake.

According to The Random House Historical Dictionary of American Slang, My Living Doll is the source of the science fiction phrase "Does not compute" in popular culture.

[24] My Living Doll producer Howard Leeds went on to create Small Wonder, a 1980s sitcom featuring a young girl robot named Vicki.

[citation needed] In 2018, Jack Chertok Television Productions producer Peter Greenwood apparently had posts on his LinkedIn account stating that he had begun active development of a new My Living Doll limited series; his account also featured a bound set of the original series scripts as part of the post.

[25] The posts may also have stated that the reboot "would be more in tune with present-day morals and would change a great deal of the format to highlight the character, based on the current need for positive, intelligent and meaningful female role models.

"[25][better source needed] It has been speculated that the Star Trek: Voyager character Seven of Nine's name is a homage to Rhoda's original designation as AF 709.