The opening night cast included Shirley Booth as Ruth and Jo Ann Sayers as Eileen, with Richard Quine and Morris Carnovsky in supporting roles.
Eileen McKenney, the inspiration for the title character, and her husband, novelist and screenwriter Nathanael West, were killed in a car accident in Southern California four days before the Broadway opening.
Alexander Hall directed a cast that includes Rosalind Russell as Ruth (in an Academy Award–nominated performance[2]) and Janet Blair as Eileen, with Brian Aherne, George Tobias, Allyn Joslyn, Elizabeth Patterson, Grant Mitchell, Jeff Donnell, and Richard Quine in supporting roles.
The cast includes Betty Garrett as Ruth and Janet Leigh as Eileen, with Jack Lemmon, Bob Fosse (who choreographed the musical numbers), Kurt Kasznar, Dick York, Arnold Stang, and Tommy Rall in supporting roles.
A pilot for a television series based on the short stories and subsequent film adaptations aired on NBC as an episode of Alcoa-Goodyear Theater titled "You Should Meet My Sister" on May 16, 1960, starring Elaine Stritch as Ruth and Anne Helm as Eileen.