[1] Six weeks after the events of "My Struggle", Scully arrives at FBI headquarters to find that Mulder has disappeared after watching an excerpt from Tad O'Malley's online news broadcast (which had been revived).
Designed to strip humans of their immune systems, this contagion quickly manifests itself nationwide, with Scully and Einstein noting a sharp increase in the number of patients admitted to hospitals and triage centers.
Miller finds a phone-tracking app on Mulder's computer, notes his position in Spartanburg, South Carolina, and leaves Washington in order to track him down, while Einstein questions Scully's medical theories.
Scully, accepting that Einstein may be correct, receives a phone-call from former X-Files agent Monica Reyes (Annabeth Gish), who asks to meet, claiming that she knows how to develop a vaccine.
During their meeting, Reyes reveals that, shortly after the closure of the X-Files, she was contacted by the badly injured Cigarette Smoking Man, who had survived the confrontation in New Mexico.
Reyes also reveals that she has spent the past twelve years assisting Cigarette Smoking Man and that Scully will survive the coming apocalypse due to her alien DNA that was given to her through her abductions and the experiments performed on her, one of the "chosen elite".
[4] The episode's ending scene set on the 14th Street Bridge was filmed on the Georgia Viaduct in Vancouver, British Columbia on September 2, 2015, near Rogers Arena.
The consensus reads: "Arguably noble intentions notwithstanding, 'My Struggle II' serves as a disappointingly sloppy conclusion to The X-Files' long-awaited revival — and a painfully persuasive argument that the show was better left 'out there'.