Goodwyn led the group from its inception and garage band roots to its multiplatinum sales peak.

[6] In January 2003, he received an ECMA Lifetime Achievement Award for his impact on the music industry of Atlantic Canada.

It was to be an all-blues album featuring guest performers such as Amos Garrett, David Wilcox, Frank Marino, Kenny "Blues Boss" Wayne and Rick Derringer.

[13] In 2022, Goodwyn received the Singapore International Festival of Arts award for his song "For Ukraine", judged in the "best social impact music/art" category.

[13] On December 20, 2022, Goodwyn retired from touring with April Wine due to his diabetes and poor health.

[12][13] He continued to write material for the band, and gave his final live performance with April Wine on March 2, 2023, in Truro, Nova Scotia.

In 2014 he decided to take a step back from April Wine, the band started playing fewer shows as Myles searched for a replacement for himself in the group citing health reasons and no longer wanting to be on the road.

In 2022 He announced that he would be retiring due to health concerns in March 2023, having found what he viewed as a suitable replacement for himself within the group and no longer wanting to travel frequently.