[5] She is best known for her roles in films such as Vamsam (2010), Kedi Billa Killadi Ranga (2013), Romeo Juliet (2015), Kanchana 3 (2019), Namma Veettu Pillai (2019), Petromax (2019), Aranmanai 3 (2021) and Vikram (2022).

Nandhini went on to study at Meenakshi Matriculation School, Madurai and Ambiga College of Arts and Science, Anna Nagar where she completed her Bachelor of Business Administration (BBA) degree.

She later made her television debut with the comedy reality show Kalakka Povathu Yaaru where she participated as a contestant.

[7][8] She also appeared in television shows such as Amudha Oru Aacharyakuri, Pandian Stores, Aranmanai Kili and Chinna Thambi.

She also played a crucial role in the 2021 web series November Story alongside actors Tamannaah, G. M. Kumar and Pasupathy.