Myoglobinuria is the presence of myoglobin in the urine, which usually results from rhabdomyolysis or muscle injury.

Therefore, among the possible signs and symptoms to look for would be:[2] Trauma, vascular problems, malignant hyperthermia, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.

Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis.

The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition, which can cause acute kidney injury.

Adding sodium bicarbonate to the IV fluids will cause alkalinization of the urine, believed to reduce the breakdown of myoglobin into its nephrotoxic metabolites, thus preventing renal damage.