Myrtle is a town in Union County, Mississippi, United States.

Myrtle is rooted in a settlement known as "Candy Hill," which was established about 2 miles (3.2 km) south of the town's present location in 1857.

Following the construction of the Kansas City, Memphis and Birmingham Railroad in the 1880s, the town shifted northward to its present location.

According to the United States Census Bureau, the town has a total area of 0.6 square miles (1.6 km2), all land.

The town of Myrtle is served by the Union County School District.