It is native to the southeastern United States (Mississippi, Alabama, Florida, Georgia, South Carolina).

[4] It is an evergreen tree that can reach 12 meters (39 feet) tall, also appearing as a shrub in drier sites.

Quercus myrtifolia also grows better in shaded and upper dune environments.

[8] It occurs in sandy soils along coastlines up to 350 feet (110 m) above sea level.

[17] Increased levels of CO2 in the environment of Quercus myrtifolia led to a decrease in leaf area.

[20] It is also possible that mature Myrtle Oaks eventually stop producing acorns making fires important for the growth of new trees.

[20] Quercus myrtifolia displays resiliency to prescribed and lightning caused burns on the Florida Lake Wales Ridge.

[22] After palmetto scrub fires Q. myrtifolia managed to reach preburn values within 5 years.

A dry spring season is known to greatly decrease its growth rate.

If growing a Myrtle Oak one should plant in full sun and well drained soil.

[28]  If it is planted outside it should be protected from pests, and buried at a depth equal to the diameter of the acorn.