The town of Mysen grew up around the station, and soon features the municipal center, shopping and industry.

The railway engineers originally favored a bypass, but this was overruled by Parliament on 4 June 1874.

This had the added bonus of being close to the ferry quay at Grønsund and was a central transport hub in the community.

These proposals called for a line traversing the municipality from Moss via Eidsberg to Ørje.

[4] The station and line opened on 24 November 1882,[5] although temporary traffic had taken place since July.

[7] Also farmers benefited, as the railway made it possible to export milk to the capital.

[9] Originally there was a daily morning train starting in Mysen and running to Oslo and then returning.

[11] The Norwegian resistance movement carried out a sabotage at Mysen Station in 1943 in which both the switches and two locomotives were blown up.

This led to a major change in the traffic pattern on the Eastern Østfold Line.

[16] It also demolished the original station and sold the property to allow Citadel-complex to be built.

It was the first Norwegian line to utilize European Rail Traffic Management System.

[20] Mysen Station is situated on the Eastern Østfold Line, 39.47 kilometers (24.53 mi) from Ski Station and 64.77 kilometers (40.25 mi) from Oslo S, at an elevation of 106.7 meters (350 ft) above mean sea level.

[5] The station has two side platforms which are 250 meters (820 ft) long and 76 centimeters (30 in) tall.

[25] Mysen is served with hourly L22 trains operated by Vy's Oslo Commuter Rail.

The trains continue onward along the Drammen Line terminating at Skøyen Station.