His subsequent films Anjathe (2008), Nandalala (2010) and Onaayum Aattukkuttiyum (2013) and Pisaasu (2014) received critical acclaim.

[5] Shanmugha Raja chose Mysskin as his assumed name, inspired by Prince Myshkin, the protagonist in Fyodor Dostoevsky's novel The Idiot.

[6] Mysskin made his directorial debut in 2006 with the low-budget film Chithiram Pesuthadi, which went on to become one of the biggest hits of the year.

[7] Mysskin went on to direct Nandalala (2010), a film loosely based on Takeshi Kitano's Kikujiro (1999) and being completely different from his first two ventures.

Mysskin himself chose to play the mentally challenged character (marking his major acting debut) after the script was turned down by many established actors.

Pisaasu (2014) which has the signature style of Mysskin has been produced by director Bala's home banner B Studios.

He is known for his peculiar combat sequences using elaborate storyboard[19][20] and real unarmed martial strikes and stances;[21] unconventional shots (like close-ups of feet); diegetic sound, light, silhouette and shadow; stage techniques (like monologue, face-floor, motion-freeze); staccato background score; meticulous scene and set construction; irony-laden dialogues; ellipses; minimalism; deep characterization (with archetypal hairdo, dress, accent, posture, gesture, locale, furniture); limited use of song choreography; and neo-noir renditions where the lead role is not infallible.

[24] His assistant directors like G. R. Adithya [25] and Sri Ganesh have also made successful films like Savarakathi and 8 Thottakkal.