Although bearing an external resemblance to the earlier aircraft, the Mystère IV was in fact a new design with aerodynamic improvements for supersonic flight.

The first 50 Mystere IVA production aircraft were powered by British Rolls-Royce Tay turbojets, while the remainder had the French-built Hispano-Suiza Verdon 350 version of that engine.

[6] Israeli Mystères flew a total of 147 sorties during the war, for the loss of a single aircraft, shot down by ground fire on 2 November.

[8] Israel planned to replace the Mystère IV with the Douglas A-4 Skyhawk, but 109 and 116 Squadron still operated the French fighter on the outbreak of the Six-Day War.

The Mystère was used as a ground attack aircraft during the war, flying 610 sorties, claiming three Arab aircraft (two MiG-17s and a Jordanian Hawker Hunter) shot down for the loss of seven Mystères, five to ground fire and two by enemy fighters (one by an Egyptian MiG-21 and one by a Jordanian Hunter flown by PAF pilot Saiful Azam).

[11][12] During the beginning of this offensive a PAF F-104 shot down an Indian Air Force Mystère IV with one of its AIM-9 Sidewinder missiles making the first combat kill with a Mach 2-capable aircraft.