[1] Myszyniec was founded in 1654 by the Jesuits in accordance with a royal privilege issued by King John II Casimir Vasa.

In 1708, the local Kurpie led by regional Polish folk hero Stach Konwa defeated the invading Swedes during the Great Northern War.

In 1719, King Augustus II the Strong established annual fairs and weekly markets in Myszyniec.

In the first days of the German invasion of Poland, which started World War II, on September 1–4, 1939, it was the site of fierce Polish defense, however, it eventually fell to Nazi Germany, which then occupied the town until 1945.

The officially protected traditional dish of Myszyniec are pierogi with blueberries, often served with smetana or honey (as designated by the Ministry of Agriculture and Rural Development of Poland).