Michael Mzwandile Makwayiba is a South African trade unionist.
Born in Ntlangaza, in the Eastern Cape, Makwayiba began working on an apple farm in Grabouw.
In 1993, the union decided to merge into the National Education, Health and Allied Workers' Union (NEHAWU), and Makwayiba became deputy chair of its Western Cape region, and chair of its Cape Town branch.
In 1997, he was elected as chair of the union's Western Cape region, also becoming chair of the Congress of South African Trade Unions in the Western Cape.
In 2016, he was additionally elected as president of the World Federation of Trade Unions.