After that he joined the National Assembly in the May 2014 general election, and he served two years as a deputy minister in the government of President Jacob Zuma.

In December 2022 he was elected to a five-year term as a member of the ANC National Executive Committee.

[4] Before he became a full-time politician, Masina worked in various public agencies, including as a chief director in the Department of Mineral Resources, director for economic empowerment in the Ekurhuleni Metropolitan Municipality, programme manager in the Ntsika Enterprise Promotion Agency, deputy director-general in the provincial Department of Sport, Arts, Culture and Recreation in Gauteng, director for business development in the Department of Trade and Industry, and general manager for empowerment at Uthingo Management.

[4] He reportedly supported President Jacob Zuma's bid for re-election at the ANC's 53rd National Conference in December 2012; at the time this was an unpopular position in Gauteng.

[3] Announcing his second cabinet on 25 May 2014, President Zuma named Masina as Deputy Minister of Trade and Industry.

[11] In the early years of his term as chairman, Masina established himself as a rival of the incumbent provincial leadership of the party in Gauteng, which included Paul Mashatile and David Makhura; among other things, these provincial leaders did not share Masina's support of President Zuma.

[23][24] Indeed, in October 2017, Masina told News24 that he would resign as ANC regional chairperson rather than serve under Dlamini-Zuma's opponent, Cyril Ramaphosa.

[28] In 2020 Masina was sanctioned by his own party after he Tweeted support for Malema's proposal that the "white economy should be allowed to collapse".

[29][30] Masina was re-elected to his second term as ANC regional chairperson in July 2018, now with Jongizizwe Dlabathi as his deputy.

[39] After his removal from the mayoral office, Masina remained in Ekurhuleni as an ordinary proportional-representation councillor and the leader of the ANC's opposition caucus.

On 31 March 2022, police officers forcibly removed him from a council meeting, allegedly after he disrupted a debate on Campbell's State of the City address.

[40] He also continued to serve as ANC regional chairperson: at an elective conference in May 2022, he narrowly defeated a challenge to his incumbency, receiving 163 votes against Doctor Xhakaza's 151 in a contest marred by disruptions and allegations of electoral improprieties.

Masina was reportedly instrumental in orchestrating the motion,[43] and observers expected him to return to the mayoral office at the head of a new ANC–EFF coalition.

[50] However, the conference elected Masina to his first five-year term as an ordinary member of the ANC National Executive Committee.

[51] After his election to the National Executive Committee, he stepped down as Ekurhuleni regional chairperson, as required by ANC rules.

In addition, on 10 July 2024,[53] he was elected as the chairperson of Parliament's Portfolio Committee on Trade, Industry and Competition.