The Náprstek Museum (Czech: Náprstkovo muzeum) is a museum of Asian, African and Native American art located in Bethlehem Square (Czech: Betlemske namesti) in Prague, Czech Republic.

The museum is situated in the former brewing and wine-making compound of U Halanku in the Prague Old Town.

The museum, originally private, was founded in 1874[1] by Czech national revivalist politician Vojtěch Náprstek in his former family brewery, as the Czech Industrial Museum.

In the 19th century the museum was one of the cultural and educational centres of the Czech intelligentsia.

Much of its collection comes from Náprstek and his friends who were Czech expatriates, travellers and ethnographers.