Born in Villa Celina, La Matanza, Buenos Aires Province, Lorenzo was a product of Argentinos Juniors' youth categories.

After two seasons as a starter, he had one-year spells at Banfield, Ferro Carril Oeste, Boca Juniors and Primera B Nacional side Quilmes, retiring with the latter in 1998.

[2] After featuring in the 1988 Summer Olympics, Lorenzo made his international debut with the Argentina national team on 6 July 1988, in a 2–2 friendly against Saudi Arabia.

He was included in Carlos Bilardo's 23-man squad for the 1990 FIFA World Cup, featuring in two matches in the group stage before starting in the final against West Germany.

[6] On 2 June 2022, the Colombian Football Federation announced Lorenzo as head coach of the national team for the following four years;[7] he remained in charge of Melgar until July.