He was chief minister of Central Province (present day Madhya Pradesh) in the 1930s as a Congress politician.
[3] Khare resigned from the Legislative Council in pursuance of the mandate by the Lahore Congress and was imprisoned for participating in Civil Disobedience Movement.
From 1935 to 1937 he was a member of the Legislative Assembly where he initiated the Arya Marriage Validation Bill which was later put on the Statute Book.
Khare was a member of the Viceroy's Executive Council from 7 May 1943 to 3 July 1946 where he was in charge of the Commonwealth Relations Department.
Khare was appointed as the Premier or Chief Minister of the first elected government of the Central Provinces and Berar in August 1937.
[6] His sacking of Ravi Shankar Shukla, Dwarika Prasad Mishra and D S Mehta led to disciplinary action against him by the Congress President Subhas Chandra Bose.
He wrote a pamphlet accusing Mahatma Gandhi and Sardar Patel for his ouster from party titled "To my Countrymen: My Defence".
After the assassination of Mahatma Gandhi, Khare was put under house arrest in Delhi on suspicion of being a part of the conspiracy with Nathuram Godse and Narayan Apte.