[3] Beginning with its construction in 1911, it served as the principal home and studio of artist N.C. Wyeth (1882-1945).

[2][4] The Wyeth House and Studio are located in a rural-residential area southeast of the village center of Chadds Ford, on the south side of Murphy Road.

The house is a two-story Colonial Revival structure, designed for Wyeth by William Draper Brinkle and built in 1911.

[4] N.C. Wyeth was renowned as one of the leading illustrators of the first half of the 20th century, his works appearing in Harper's, Scribner's, McClure's, and the Saturday Evening Post.

He purchased this property with funds made from his first major commission, a series of illustrations for an edition of Robert Louis Stevenson's Treasure Island.