The product features former Michigan Wolverines standout and Heisman Trophy winner Desmond Howard on the cover.

In "Race for the Heisman", you begin as a high school standout hoping to sign with a major college program.

If they execute a big play, action pauses and the camera zooms in on the tackle, juke move, etc.

[3] Retained from the previous version are the Top 25 toughest places to play (The University of Florida's Ben Hill Griffin Stadium, or "The Swamp", remains #1 in 06), a still-revamped Dynasty Mode (with a new In-Season Recruiting feature), all-time and historic teams, Create-a-School, and much more.

The main menu screen features a highlight reel with footage of plays made by some of the most famous players in college football history, including Ricky Williams, Bo Jackson, Archie Griffin, Charles Woodson, Herschel Walker, LaDainian Tomlinson, Barry Sanders, LaVar Arrington, Warren Sapp, Ray Lewis, Tim Dwight, Randy Moss, Ron Dayne, Warrick Dunn, Lawrence Taylor, Tim Brown, and Peyton Manning.

[5][6] Prior to the release of NCAA Football 06, the only music featured in the game were fight songs of several major colleges.

The music features mainly college rock, punk and post-punk selections, including Bad Religion, The Clash, NOFX and The Mr. T Experience.

Next Generation ranked it as the 40th highest-selling game launched for the PlayStation 2, Xbox or GameCube between January 2000 and July 2006 in that country.