NCAA Season 81 was the 2005–06 season of the National Collegiate Athletic Association (Philippines).

To usher in the new season, Letran and the other NCAA member schools performed the opening ceremonies at the Araneta Coliseum, followed by four basketball games on June 25, 2005.

De La Salle-College of Saint Benilde won its first General Championship honors for the Seniors division, while the San Sebastian Recoletos High School won its second Juniors General Championship, via tiebreakers, when La Salle Green Hills emerged with an equal number of points.

Arranged by order of conclusion: ¹ Not a part in the tabulation of the General Championship ¹ Since San Sebastian had more championships (4) than LSGH (3), San Sebastian won the General Championship, despite being tied for first place.

² Mapua did not send representatives in the Juniors division