[1][2][3] NDHU CSAE was founded by a batch of Taiwanese-American scholars from United States, Canada.

[5][6] In 1994, National Dong Hwa University was established, founding the Graduate Institute of Applied Mathematics as a precursor to NDHU College of Science and Engineering.

The Graduate Institute of Applied Mathematics attracted many oversea scholars, including Fu James, Professor of Statistics at University of Manitoba,[7] Wu Tiee-Jian, Professor of Mathematics at University of Houston, and Research Fellows Cheng Philip E. and Chiang Tzuu-Shuh from Institute of Statistical Science at Academia Sinica.

[8][9][10] With Hsia Yu-Ping, Chair of Chemistry at California State Polytechnic University, Pomona, returned from United States, NDHU College of Science and Engineering (NDHU CASE) was founded in 1995 as Taiwan's 2nd institution for Natural Sciences and Engineering to serve the interdisciplinary trend of both disciplines.

These graduate institutes were founded by many Taiwanese scholars from United States, including Kuo Sy-Yen, Professor of Electrical and Computer Engineering at University of Arizona, and Wong Ming-Show, Research Scientist of Materials Research Center at Northwestern University as Founding Director.

In 2010, NDHU CSAE established the Department of Opto-electronic Engineering and MS program in Statistics.

There are eight major tracks for PhD students follow at NDHU College of Science and Engineering:[27][28] There are eight specialization M.S.

[30] These programs operate on a modular system, allowing students to design their curricula and manage their study pace.