New Explorations into Science, Technology and Math, abbreviated NEST+M, is a selective public school located on the Lower East Side of the Manhattan borough of New York City, New York, and is under the supervision of the New York City Department of Education, serving grades kindergarten through 12th grade (the only K-12 public school in Manhattan).

[1] The school exclusively enrolls New York City resident K–3 children scoring within the 97th, 98th, or 99th percentile of the gifted and talented test and sixth-graders at the 97th percentile nationwide in standardized tests administered by the New York City Department of Education for their Gifted & Talented Program.

Prospective 9th and 10th-grade students apply through the NYC High School Application Process as well as their entrance exam.

As of September 2017, Principal Mark Berkowitz eliminated the NEST+m entrance exam and published the new rubric on the NEST+m website.

The current acceptance rate for NEST+m Upper Grades is 1.3%, receiving approximately 6700 applications and 88 seats.