NGC 2506 (also known as Caldwell 54) is a mildly-elongated[6] open cluster of stars in the equatorial constellation of Monoceros, located at a distance of 12.7 kly[2] from the Sun near the Galactic anti-center.

[8] At least 94 probable members have been identified within the field of NGC 2506 based upon their radial velocities.

Compared to the Sun, the cluster is moderately metal-poor with an iron abundance of [Fe/H] = –0.3 dex.

[10] Twelve blue straggler stars have been located in the cluster, with three of them showing short-period oscillation.

Fourteen Gamma Doradus variables have been found, as well as two detached eclipsing binaries,[6] and three Delta Scuti stars.