NGC 4527 is a spiral galaxy in the constellation Virgo.

It was discovered by German-British astronomer William Herschel on 23 February 1784.

[2] NGC 4527 is a member of the M61 Group of galaxies, which is a member of the Virgo II Groups, a series of galaxies and galaxy clusters strung out from the southern edge of the Virgo Supercluster.

[3] NGC 4527 is an intermediate spiral galaxy similar to the Andromeda Galaxy[4] and is located at a distance not well determined, but usually is considered to be an outlying member of the Virgo Cluster of galaxies,[5] being placed within the subcluster known as S Cloud.

[6] Unlike the Andromeda Galaxy, NGC 4527 is also a starburst galaxy, with 2.5 billion solar masses of molecular hydrogen concentrated within its innermost regions.