NGC 4881 is an elliptical galaxy in the northern constellation of Coma Berenices.

It was discovered by the German astronomer Heinrich Louis d'Arrest on April 22, 1865.

John L. E. Dreyer described it as "faint, small, a little extended, 9th magnitude star to southwest".

[6] This object is located at a distance of approximately 309 megalight-years from the Milky Way.

[4] It has an unusually low frequency of globulars for a galaxy of this type.