It is also known as NALP11, PYPAF6, NOD17, PAN10, and CLR19.6 Being a member of the NOD-like receptor protein (NLRP) gene family, it encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region.

Based on studies of other members of the NLRP gene family with similar domain structures, it is predicted to form part of the multiprotein inflammasome complex.

[5] NALPs family controls cytokines, inflammatory responses, NF-κB activation, and likely cell death and survival.

[7] Bacterial lipopolysaccharide (LPS) is an endotoxin that can lead to lethal infection sepsis by activating innate immune responses.

NLRP11 acts as a negative regulator of type I IFN and virus-induced apoptosis by disrupting the Mitochondrial antiviral-signaling protein (MAVS) signalosome activity.

NLRP11 acts as a negative regulator of type I IFN and virus-induced apoptosis via disrupting the activity of MAVS signalosome.