The museum carries out school programs, hosts field trips for local and international primary and secondary students, and provides assistance to a variety of Northern Marianas College classes.

[1] The museum loans objects to American Memorial Park[7] and partners with the Marianas Visitors Authority, CNMI Arts Council, and other organizations for events.

The exhibit included photographs, oral or written testimonies, maps, letters, excerpts from a diary, and copies of church records from Saint Mary's Parish in Colonia, Yap.

[17] In the summer of 1999, the government of Germany turned over CNMI replicas and photocopies of maps, stamps, documents, photos, and postcards reflecting the colonization period.

Displayed objects included photographs, film clips, artifacts, maps, post cards, stamps, models, reproductions, and oral histories.

The Sugar King Foundation provided several artifacts, including a Nan'yō Kōhatsu kabushiki gaisha "Happi Coat" given to company employees in recognition for their years of service.

[24][25][26][27] The museum also displayed items and images of the Navajo Code Talkers and Atomic bombings of Hiroshima and Nagasaki and crafts made by civilians in Camp Susupe.

"[29] Objects and photographs associated with the sugar industry and South Seas Development Company (Nan'yō Kōhatsu kabushiki gaisha), including an original scrapbook donated to the museum by Director Haruji Matsue's son and grandson, were displayed.

[30] In June 2004, the crew of the Enola Gay, including Paul Tibbets, Morris Jeppson, and Theodore Van Kirk, visited the museum and donated objects to it.

[31][32] In January 2005, Takahisa Aoyagi and Takao Fukushima donated Japanese Period items related to the Nanyoji Temple and the Saipan Girls' High School to the museum.

Displayed items included candle holders, altar lamps, bells, basins, old books and illustrations, and an early twentieth century chair made of narra wood carved and upholstered in crimson velvet.

[40] In July 2005, the mayor of Aizuwakamatsu, Fukushima Prefecture, Japan and film crew creating a documentary about Haruji Matsue toured the museum.

[43] In February 2006, the museum's exhibit curator held a presentation on prehistoric Chamorro culture at San Vicente Elementary School.

[4] Pottery storage jars from the sunken galleon Nuestra Señora de la Concepción and gold pieces are located in the museum's Concepcion Collection.

The museum has a 1934 Missale Romanum (a Latin Mass book), a one hundred year-old chalice, and a pre-war Monstrance of the Blessed Sacrament, which are on loan from Bishop Ryan Jimenez of the Roman Catholic Diocese of Chalan Kanoa.

[79] Staff had to pay out of their own pockets for gallery light bulbs, lawn maintenance equipment, computers, museum vehicles and fuel, and other supplies.

[83] In March 2019, the museum partnered with the Saipan Southern High School Student Council for a carwash fundraiser to support the institution.

[87] In 2017, the United States Department of Defense, Saipan Shipping Company, and IT&E donated three twenty foot containers that were modified to hold human remains and artifacts in the museum's possession.

[82] In the late 2010s, the museum received grants from the Marianas Visitors Authority to preserve the building and to safeguard its exhibits[89] and IT&E Saipan provided phone, fax, and internet services.