Its northern terminus is at an interchange with the Utica–Rome Expressway within the Rome city limits but southeast of the inner tax boundary.

NY 233 is the most direct connection between Rome and the New York State Thruway, which it meets at exit 32 in Westmoreland.

In the hamlet of Westmoreland, NY 233 meets the New York State Thruway (Interstate 90) at its exit 32.

Just before entering the large city of Rome, NY 233 cuts through the extreme northwestern corner of the town of Whitestown.

The alignment of NY 233 has remained virtually unchanged since the route was assigned as part of the 1930 renumbering of state highways in New York.