The group signed with Epitaph Records before releasing their debut album, You Can't Spell Slaughter Without Laughter, in 2008.

After the band disbanded, Mehana and Moo began creating songs under the name I Set My Friends on Fire.

The duo then signed to Epitaph Records,[10] which released their debut album You Can't Spell Slaughter Without Laughter on October 7, 2008.

On November 21, 2008, the comedy duo Smosh had teamed up with I Set My Friends on Fire and released their first music video and second single, called "Sex Ed Rocks" which had over 20 million views.

[12] Later in September 2009, they teamed up yet again and released their second music video and fourth single, entitled "Four Years Foreplay" which attracted over 7 million views.

The group performed at The Bamboozle music festival in New Jersey on May 1, 2010, and then entered the studio for a second time on June 2, 2010, to finish their upcoming album.

[14] The first single from the album, "Excite Dyke", was released exclusively via digital download on June 15, 2010, as part of a new Epitaph compilation CD entitled "New Noise Vol.

[18] On July 18, the music video for "It Comes Naturally" was released on YouTube directed by Nicholas Lent and co-founder and ex-member Nabil Moo.

On December 9, 2016, the band announced on their Facebook page that they have signed to Tragic Hero Records and have released the first single from their upcoming fourth studio album My Uzi Holds A Hundred Round Conscience.

The tour consisted of multiple festival appearances and headline shows in small clubs, which resulted in most dates selling out.

The band went on to tour Europe in October and released a new single titled "Don't Take Me For Pomegranate" featuring rapper Lil Lotus.

On August 19, 2019, the band made a post on Instagram confirming that Caterpillar Sex did still exist and was seemingly in the finishing stages of production.

The group blends elements from a variety of genres including electronica, crunkcore, post-hardcore, metalcore, electronicore, alternative metal, screamo, dance-pop, mathcore, and glitch.