[9] In June 2016, Keïta moved to Red Bull Salzburg sister-club RB Leipzig, who had just been promoted to the German Bundesliga.

[13] On 28 August 2017, a deal was struck for Keïta to join Liverpool on 1 July 2018 after the English club triggered his £48 million release clause in addition to paying an undisclosed premium.

[17][18] Keïta made his debut for Liverpool against West Ham United on 12 August 2018 and played a part in the opening goal for Mohamed Salah in a 4–0 win.

[22] Although Keïta was injured, he won his first Liverpool title while out of the matchday squad as his team mates secured the win in the Champions League final against Tottenham Hotspur in early June.

[26] On 7 December, he provided a goal and assist in a 3–0 win away against AFC Bournemouth, a game which marked his first league start of the season.

[30] On 2 January 2020, he was named in the starting line-up against Sheffield United, but was withdrawn after sustaining a groin injury during the warm-up, being replaced by James Milner.

Ahead of Bremen's Bundesliga match against Bayer Leverkusen on 14 April 2024, Keita refused to board the team bus to the stadium and headed home, after being told he would not be part of the starting line-up.

[36] On 10 December 2024, it was announced that Keita would join Nemzeti Bajnokság I club Ferencvárosi TC on loan in January.

[41] On 12 November 2015, Keïta scored his first international goal in three years, in a 1–0 away win against Namibia in the first leg of the second round of 2018 FIFA World Cup qualification.

[42] Three days later in the return leg – in Morocco due to the Ebola virus epidemic in Guinea – he scored again in a 2–0 win.

[43] Manager Paul Put chose Keïta for the 2019 Africa Cup of Nations in Egypt, where he was affected by injuries.

However, Guinea were eliminated after a loss to Gambia, a match Keïta could not play due to yellow cards accumulation.

They also noted, however, that he is able to distribute the ball with range and accuracy, and score goals, which has instead frequently led him to be compared to Brazilian-Portuguese former playmaker Deco.

[46] David Usher of ESPN has described Keïta as an energetic midfielder, with good defensive qualities, which also allows him to play in a holding role if necessary.