He finished his first full-length feature film, Los Cronocrímenes (English title: Timecrimes), in 2007, in which he also co-starred.

[3] From 2012 to 2014 he wrote and directed a segment in three different anthology horror films: The ABCs of Death, The Profane Exhibit, and VHS: Viral.

Vigalondo's wrote and directed the 2016 film Colossal, which is a twist on the Kaiju genre and an homage to the Godzilla franchise.

Before starting production on Colossal, Vigalondo described his plan as to make a serious film with "old school" practical effects on a low budget.

[5] Vigalondo's directed the Hulu original film Pooka, released December 2018 in the Into the Dark series.