Four months after du Bospertus started modelling, she was booked by Herb Ritts for a shampoo advertisement, and became known for her very short black hairstyle and haircut.

She was featured on the covers of fashion magazines including Vogue, Marie Claire, Elle, Mademoiselle, and Vogue Paris, and worked with photographers such as Albert Watson, Steven Meisel, Patrick Demarchelier, Tiziano Magni, Gilles Bensimon, and Bruce Weber.

She appeared in fashion editorials and advertising campaigns for designers including Giorgio Armani, Ralph Lauren, Chanel, Marco Coretti, Escada, Fendi, Kenzo, Missoni, Sportmax, Strenesse, Emanuel Ungaro, Versace, Yves Saint Laurent, Levi's, and Versus.

On the runway, she walked for designers such as Karl Lagerfeld, Oscar de la Renta, Christian Dior, Valentino, Marco Coretti, Versace, Dolce & Gabbana, Chanel, Carolina Herrera, Giorgio Armani, Oscar de la Renta, Krizia, Laura Biagiotti, Les Copains, Claude Montana and Roberto Cavalli.

In early 2009, she catwalked for Etro during their autumn-winter 2009/10 Men's Show and was featured in a series of pictures shot by Bob Krieger that were exhibited during the opening event at First, the Vicenzaoro jewellery fair.