Nadowli District is a former district that was located in Upper West Region, Ghana.

Originally created as an ordinary district assembly in 1988.

The district assembly was located in the western part of Upper West Region and had Nadowli as its capital town.

Nadowli District has a low-lying topography generally undulating between 150 m and 300 m but in some parts reaching an average of 600 m. Agriculture is the most important economic sector of Nadowli District, accounting for about 85% of the labor force.

The commercial and industrial sectors are less developed.