The nagin transforms into a beautiful woman (Mallika Sherawat), and is later helped by police inspector Vikram Gupta (Irrfan Khan) and his wife, Maya (Divya Dutta), who is infertile, causing a strain in their relationship.

Inspector Gupta tries to help the nagin find her mate, but at the same time, tries to investigate the murders, unaware she is responsible for them.

Finally, Nagin reaches George's hideout where she reclaims her mate and they have sex, leading her to become pregnant.

Wearing a suit that hides his heat signature, he lures her by using her dying mate as bait for a trap.

"[12] Mooppan Raghavan, tribal leader of Thalikakal settlement in Kerala, and over a dozen members of his tribe were recruited as extras.

[14] At the Cannes Film Festival, Mallika Sherawat promoted Hisss by posing with a 22-foot-long (6.7 m) Burmese python on the red carpet.

Nikhat Kazmi of Times of India gave it 2 out of 5 stars and stated, "A film like Hisss should have scored with its special effects.

On one hand, we celebrate the new stories being told in our films, and on the other, we churn out a Hisss, which is badly scripted, poorly enacted, and carelessly directed.

The outrageous plot involves this ichchadhari Nagin emerging as something of a feminist superhero who comes to the rescue of various tormented women, even as she's seeking out her kidnapped partner.

Anupama Chopra from NDTV gave it 1.5 stars out of five and stated that "Hisss has marginally better special effects and much more nudity but the script is so deliriously inept that, in comparison, the average Ramsay horror film looks like a class act."

Mayank Shekhar from Hindustan Times gave it 1 star out of five and stated that "This is pornography for the hormonally demented teen.

[23][24] The soundtrack consists of six original recordings, composed by Anu Malik, David Kushner, Panjabi MC, Alexander Von Bubenheim, Salim–Sulaiman and Julian Lennon, and lyrics penned by Sameer, Shruti Haasan, Mallika Sherawat, Shweta Pandit, Shraddha Pandit and Sayeed Quadri.