She co-founded award-winning blog Adventures from the Bedrooms of African Women and has written for The Guardian and Open Democracy.

[2] Sekyiamah is the convener for Fab Fem, a feminist group that meets regularly in Accra.

[4][5][6] She wrote the Communications Handbook for Women’s Rights Organisations and has had short stories published in anthologies in many countries.

[7] Sekyiamah has written widely on the sexuality of African women and has also had an article ("Standpoint: Adventures from Our Bedrooms – Blogging about diverse erotic experiences") published in the peer-reviewed academic journal Feminist Africa.

[11][12] In 2021, Sekyiamah had an anthology entitled The Sex Lives of African Women published by Dialogue,[1][13] described in a review by Margaret Busby as "an extraordinarily dynamic work".