[4] Mizuki was trained as an enka singer, releasing one single under her birth name in 1993 and made her debut as a voice actress in 1996.

Her prominent roles include Hinata Hyuga in the long-running ninja series Naruto as well in Boruto: Naruto Next Generations, Tamao Tamamura in Shaman King 2001 and 2021, Colette Brunel in Tales of Symphonia, Fate Testarossa in Magical Girl Lyrical Nanoha, Tsubasa Kazanari in Symphogear, Moka Akashiya in Rosario + Vampire, Tsubomi Hanasaki (Cure Blossom) in Heartcatch Precure!

She also had official dubbing roles in live action version of Itazura na Kiss from Korea and Taiwan, as well in Hunger Games film series as Katniss Everdeen (played by Jennifer Lawrence).

[10] Mizuki released an image song single titled "Girl's Age" under the name Chisato Kadokura in 1997.

Fate Testarossa from Magical Girl Lyrical Nanoha, Nyamo from Love Hina, Hinata Hyūga from Naruto, Wrath from Fullmetal Alchemist (2003) and Tsubomi Hanasaki from Heartcatch Precure!).

Nana Mizuki voices Microsoft's Japanese Windows 7 unofficial "OS-tan" mascot, Nanami Madobe.

The news was broadcast during her Live Academy 2010 tour, held in Kanagawa, Osaka, Aichi, Miyagi, Fukuoka, Ehime Prefecture Niihama Cultural Center's Hall.

In 2010, she also participated in 61st NHK Kōhaku Uta Gassen singing "Phantom Minds", the single which had topped Oricon Charts.

[18] Mizuki has participated in the 60th (2009), 61st (2010), 62nd (2011), 63rd (2012), 64th (2013) and the 65th (2014) edition of the Kōhaku Uta Gassen produced by Japanese public broadcaster NHK.

[21] In March 2014, at the 64th Annual MEXT Art Encouragement Prizes Nana Mizuki was recognized as Rookie of the Year in the Popular Entertainment division.

[22] She held her second overseas solo concert in Singapore (September 27, 2014) and Taiwan (October 4–5, 2014) entitled "Nana Mizuki Live Flight 2014+".

[citation needed] On September 30, 2017, she performed in the opening ceremony of 72nd National Sports Festival of Japan, held at Ningineer Stadium in Ehime, in front of Emperor Akihito, Empress Michiko and approximately 20,000 attendees.