Lescavage hails from Port Carbon, Pennsylvania, and is a licensed nurse in that state.

Since receiving her commission in May 1972, Rear Admiral Lescavage has held numerous senior executive leadership positions to include: Assistant Chief, Health Care Operations, Bureau of Medicine and Surgery (2001–2002); Deputy Assistant Chief for Health Care Operations, Bureau of Medicine and Surgery (1999–2001); Commanding Officer, Naval Hospital, Corpus Christi, Texas (1997–1999); Executive Officer, Naval Hospital, Great Lakes, Illinois (1995–1997); and Commanding Officer, Fleet Hospital Five (1995–1997).

Additionally, she served as a Congressional Fellow in the Office of United States Senator Daniel K. Inouye [Hawaii] (March 1993 – January 1995).

Rear Admiral Nancy J. Lescavage was assigned as the Regional Director of the TRICARE Regional Office – West, San Diego, California, overseeing Managed Care Support contracts and an integrated health care delivery system in twenty-one states covering more than 2,700,000 TRICARE eligible beneficiaries.

Rear Adm. Lescavage has had numerous articles published and has been a keynote speaker on many occasions on a variety of topics.