In an interview with Tom Snyder in 1998, she joked that she "was given detention a few times" for not adhering to the strict rules of school, which included not wearing her favorite patent leather shoes.

McKeon portrayed Inspector Jinny Exstead on the Lifetime police drama The Division from 2001 to 2004, with her pregnancy incorporated into the storyline of the last year of the series.

From 2009 to 2010, she appeared in a recurring role in the Disney Channel Original Series Sonny with a Chance as Connie Munroe, the mother of Demi Lovato's title character.

[11] She has a brief cameo appearance in 2019's You Light Up My Christmas, a movie starring her Facts of Life co-star Kim Fields.

[12] Also in 2019, McKeon announced on social media her involvement in a new, planned Amazon series based on the Lauren Oliver young adult novel Panic.

While McKeon was on The Facts of Life, she and her parents were granted a private audience with Pope John Paul II.

[14] She described the experience to interviewer Tom Snyder in 1998 as "electric," explaining, "In every rendering of every artist, you see this aura that's painted around figures...He has that in life.

In 2003, McKeon married film technician Marc Andrus, after meeting eight years prior on the set of the Hallmark movie, A Mother’s Gift.