She left the Gauteng Provincial Legislature in the 2019 general election and in 2021 was appointed chairperson of the board of South Africa's Central Drug Authority.
Mayathula-Khoza was born and raised in Senaoane in Soweto in the former Transvaal, now part of Gauteng province.
[1] In early June 2009, Nomvula Mokonyane, then the Premier of Gauteng, appointed Mayathula-Khoza to the Gauteng Executive Council as Member of the Executive Council (MEC) for Agriculture and Rural Development; she succeeded Nomantu Nkomo-Ralehoko, who had resigned shortly after being appointed to the office in May following the 2009 general election.
[5] On 2 February 2016, Makhura announced a reshuffle in which Mayathula-Khoza was moved to the social development portfolio.
[6] Mayathula-Khoza did not seek re-election to the provincial legislature in the 2019 general election;[4] she said that she intended to leave government to complete a Master's degree and establish a charitable foundation,[3] although she remained active in her local ANC branch, Gauteng's Mzala branch.