The entire railway station has 128 escalators and 28 platforms (a combination of island-platforms and side-platforms).

Solar panels cover the majority of the railway station roof and are capable of providing 228 MWs of electricity within 25 years.

[9] The design inside the building incorporated traditional architectural elements to reflect the history of Nanjing,[10] for it used to be the capital of 6 different ancient dynasties with massive resources.

[11] The construction has successfully combined Nanjing's history and modernity by involving dual eaves, colonnades, dougong brackets, brickwork and paper-cut into decorations.

[13] It boosted the growth of commercial districts, shopping centers, and business parks, serving as a landmark for modern urban infrastructure.

In the summer transport season of 2023, Nanjing South handled over 10 million passengers, with an average of more than 650 train services operating daily.