The player controls Jake, a cyborg militant and the protagonist of the game, and explores a large island stage.

To achieve this goal, the United States collected the world's foremost scientists, analysts and businessmen and placed them in a secluded community.

As Jake, the player's goal is to assist the daughter of a brilliant scientist in her attempts to restore order to the island and its people by destroying the main computer which manages the activities of the nanomachines.

Nano Breaker was developed and published by Konami and was produced by Koji Igarashi, known for his contributions to the company's Castlevania franchise.

[15] Alex Navarro of GameSpot gave it a 5.5/10 rating saying that producer Koji Igarashi failed to deliver what was exciting in Castlevania games to Nano Breaker.