From June 1998 to March 2000, she was part of the ISS Centrifuge team (life science experiment facility) conducting conceptual framework and preliminary design.

[6] Since 2001, Yamazaki has participated in ISS Advanced Training and supported the development of the hardware and operation of the Japanese Experiment Module.

After returning to Earth, after spending a total of 15.12 days in space,[12] Yamazaki continued her studies and research University of Tokyo since December 2010.

[6] Since 2011, Yamazaki has been involved with promoting STEM activities as well as being a member of the Japanese government Space Policy Committee[13][14] In July 2018, Yamazaki co-founded the Space Port Japan Association, which is an organization to support efforts to open spaceports in Japan through collaboration with companies, groups and government institutions.

[15] She is an adviser to the Young Astronaut Club, and Chairman of the Women in Aerospace program of the Japan Rocket Society.