After featuring on the Disney Channel series Life Bites (2008–2009), she earned recognition for starring in the television musical film Lemonade Mouth (2011), for which she performed on its chart-topping eponymous soundtrack.

In 2019, Scott starred in the action comedy Charlie's Angels and gained wide attention for playing Jasmine in the fantasy film Aladdin.

After a three-year break from acting, she returned with the Netflix thriller miniseries Anatomy of a Scandal (2022) and received praise for her performance in the horror film Smile 2 (2024).

[2] Her mother Usha Scott (née Joshi), who was born in Uganda and emigrated to the United Kingdom at a young age, is Gujarati.

[11] Scott was discovered by British pop singer Kéllé Bryan from the girl group Eternal, who signed her as a client.

In 2010, she was cast as Mohini "Mo" Banjaree in the acclaimed 2011 Disney Channel original film Lemonade Mouth, her first role in an American production.

[33] In his review for the San Francisco Chronicle, critic Mick LaSalle found Scott to be the "real star" of the film and that she "thrives and gives everything to her new power anthem ['Speechless']".

[38][39] Also in 2019, Scott starred as one of the three leads, alongside Kristen Stewart and Ella Balinska, in the action comedy Charlie's Angels, the third installment within the franchise of the same name, released in November.

[43] In 2020, Scott was cast in the Netflix series Anatomy of a Scandal, as parliamentary aide Olivia Lytton,[44] and in the science fiction film Distant.

[51] Benjamin Lee of The Guardian called Scott "a fantastically committed goes-to-hell-and-back scream queen"[52] and Owen Gleiberman of Variety believed she gave the film "a genuine emotional center.

[58] She is a UK ambassador to the Christian charity organisation Compassion International, sponsoring children and families living in poverty.

[61] She holds a black belt in karate, having studied it since her youth, which she credits as helpful with her roles in Power Rangers and Charlie's Angels.