[9] His songs, along with those of his peers and contemporaries (such as Little Richard, Chuck Berry, and Fats Domino), were among the first wave of African-American pop music to become noticed and popular with white audiences.

[16] Brown's Savoy Records hit, "Piddly Patter" was featured in the John Waters film, Cry-Baby, starring Johnny Depp.

[21] The album, produced by Scott Cable, featured the guitarists Sean Costello, Bob Margolin, Junior Watson, Joe Sunseri and other special guests performing Brown's hits and several new songs.

In the fall of 2007, Nappy Brown was Living Blues magazine's September cover artist, and followed that honor with a European tour.

[23] At the ceremony for the Blues Music Awards in May 2008, Brown gave one last electrifying performance, capping an incredible comeback year.

[24][25] On June 1, 2008, following a performance at the Crawfish Festival in Augusta, New Jersey, Brown fell ill due to series of ailments and was hospitalized.

Nappy Brown's 1956 recording of "Open Up That Door", is featured in a national commercial for Google, as of June 2020.