As a high-school student she protested for the overthrow of the Shah; after the Iranian Revolution, she campaigned for democracy against the Ruhollah Khomeini regime.

[2][4] Eskandari-Grünberg earned a doctorate and became a psychotherapist with the German Red Cross, and married fellow psychologist Kurt Grünberg, with whom she has a second child.

[5] Her daughter Maryam Zaree [de] became an actress, known for roles in the film Shahada and the TV series 4 Blocks and Tatort among others.

[8] After the 2021 Frankfurt local elections, in which the Greens finished first, Eskandari-Grünberg was chosen as the Bürgermeisterin (Deputy Mayor) as well as the Head of Department for Diversity, Anti-discrimination and Social Cohesion.

During the Mahsa Amini protests in Iran in 2022, Eskandari-Grünberg organised and led demonstrations in support of Iranian feminists in Frankfurt.