[4] As the National Security Advisor and General Secretary of the Supreme Council for Defence, he manages royal directives, charged by His Majesty the King on matters pertaining to national security, regional relations and youth and leads high level delegations globally, to cover various grounds that concern the Kingdom of Bahrain’s role as an active player in the global arena.

[19] In October 2022, Al Khalifa won gold at the FEI Endurance World Championship for Young Horses riding the mare Lola de Jalima in Vic, Spain.

[20][21] Earlier in June 2024, he led the Royal Endurance Team to victory in the 120-kilometer race at the Šamorín Championship in Slovakia, showcasing his exceptional leadership and competitive spirit.

[22] In September 2024, Shaikh Nasser achieved a significant milestone by winning his second consecutive title at the 160-kilometer FEI World Endurance Championship held in Monpazier, France.

[28] In March 2024, Shaikh Nasser bin Hamad Al Khalifa, as Chairman of Bapco Energies, spearheaded a strategic partnership with TotalEnergies to optimize the operations of Bahrain's Sitra refinery and enhance petroleum product trading.

[31] In addition, he signed an agreement in the Philippines in February 2014, following the devastating typhoon, to build two vocational training centers carrying the name of "Bahrain", and a 500-home residential complex.

[34] Job descriptions, roles and titles held by him include: Al Khalifa became the subject of allegations of torture after anti-government protests in 2011, during the Arab Spring in Bahrain.

At the time, he issued a royal decree permitting the army to establish military courts to deal with democracy protesters, including a committee set up to investigate "breaches by individuals associated with the sports movement during the recent unfortunate events in the Kingdom of Bahrain".

The Bahrain Football Association, headed by Sheikh Salman, threatened punishments for those who had participated in the protests, or any other act that aims to "overthrow the regime or insult national figures".

[34] In 2014, a Bahraini citizen sought the arrest of Al Khalifa in the United Kingdom following allegations that he was directly involved in the torture of three prisoners in Bahrain during a pro-democracy uprising there in 2011.

[56] In response to these concerns, the U.S. State Department reaffirmed Bahrain's status as "an important U.S. partner," emphasizing the bilateral relationship's foundation on shared interests, including counterterrorism, regional security, and countering Iran's influence in the Middle East.