She inherited a genetic characteristic called polydactyly from her father,[1] a congenital physical anomaly in humans; these supernumerary fingers or toes do not cause any problems to the carriers.

Prior to her current career, Natália had an audition for actress in Rede Globo's telenovela Estrela Guia, but her father forbade it in favor of modeling activities.

On 13 July, Natália attended the opening ceremony of the Pan American Games in Rio de Janeiro with Brazilian delegation and held the national flag at the occasion.

In 2009, Natália portrayed a minor role in Bela, a Feia, Record-Televisa partnership Brazilian version based upon Mexican La Fea Mas Bella.

On 8 August 2013, Guimarães and longtime boyfriend Leandro Scornavacca of KLB fame welcomed twin daughters Maya and Kiara.