Like other Nature journals, there is no external editorial board and editorial decisions are made by an in-house team, although peer review by external experts forms a part of the review process.

[2] Every year, the journal highlights a field, approach, or technique that has enabled recent major advances in life sciences research as the "Method of the Year".

According to the Journal Citation Reports, the journal had a 2021 impact factor of 47.990, ranking it first in the category "Biochemical Research Methods".

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